![]() ![]() Here, we investigate the impact of the context of genetic and epigenetic alterations and tumor type on the classification and report on technical aspects, such as robustness of cutoff definition and preprocessing of the data. Our model MGMT-STP27 allows prediction of the methylation status of the MGMT promoter using data from the Illumina's Human Methylation BeadChips (HM-27K and HM-450K) that is publically available for many cancer data sets. The methylation status of the O 6-methylguanine-DNA methyltransferase ( MGMT) gene is an important predictive biomarker for benefit from alkylating agent therapy in glioblastoma.
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